The study is the first of its kind to compare the impact of exclusion diets (mainly gluten and casein free) vs an un-restricted diet in autistic children. Half of the 30 participants received Bimuno® galactooligosaccharide (B-GOS®) for the duration of the 6-week feeding period, while the other half were given a placebo.
The primary outcome was that children on exclusion diets reported significantly lower scores of abdominal pain and bowel movement, as well as lower abundance of Bifidobacterium (linked to bowel health) and Veillonellaceae family. In addition, significant correlations were found between bacterial populations and faecal amino acids in this group, compared to children following an unrestricted diet.
Following B-GOS® intervention, improvements in anti-social behaviour and sleep problems were observed. A combined dietary approach resulted in significant changes in gut microbiota composition and metabolism, suggesting that combining B-GOS treatment with other intervention therapies might have a positive impact on reducing GI disturbances
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